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To understand the current situation of occupational burnout, turnover intention, and professional self-care among social workers under the context of epidemic prevention and control, and the role of professional self-care in the relationship between occupational burnout and turnover intention, this study investigated 1 066 social workers in Fujian Province with Professional Self-Care Practice Scale, and the Burnout Scale. SPSS 26.0 and its PROCESS plug-in analysis were used, the results showed that the proportion of social workers with moderate and severe occupational burnout accounted for 44.22% and 29.99% respectively, the proportion with turnover intention in the past year accounted for 25.67%, and the average score of professional self-care was (22.57±5.98) points. There was a significant positive correlation between occupational burnout and turnover intention (r=0.29, P<0.01). Professional self-care of social workers was significant negatively correlated with occupational burnout (r=-0.46, P<0.01) and turnover intention (r=-0.16, P<0.01). Professional self-care played a moderating role in the relationship between occupational burnout and turnover intention (β=-0.01, P<0.05). This paper indicated that social workers had a high degree of occupational burnout and turnover intention, low level of professional self-care under the context of epidemic prevention and control, and the attention should be paid to the protective role of professional self-care.
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Autologous ozonized blood transfusion(AOBT) is a therapy of re-transfusion of 100-200 mL of autologous blood after shaking and agitation with appropriate amount of oxygen-ozone in vitro. The oxidation of blood through the strong oxidation of ozone can enhance the non-specific immune response of the body, regulate the internal environment and promote health. This therapy has been increasingly applied in clinical practice, while no unified standard for the operation process in terms of ozone concentration, treatment frequency and treatment course had been established. This operation process of AOBT is primarily explored in order to standardize the operation process and ensure its safety and efficacy.
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Objective:To analyze the clinical characteristics of patients with spontaneous low intracranial pressure (SIH).Methods:The study is a retrospective series. The clinical data of patients with SIH who visited Beijing Hospital from May 2017 to March 2022, including gender, age, symptoms, signs, imaging findings, treatment and outcome, were collected and their clinical characteristics were analyzed.Results:Finally, 8 patients with SIH, 6 females and 2 males, aged (33.5±7.3) years, were included. There were 6 cases of acute onset, 1 case of subacute onset, and 1 case of chronic onset. Four cases had pre-onset triggers, 3 cases were exertional and 1 case was exercise. All 8 cases had orthostatic headache. Three cases were accompanied by neck pain. Six cases were accompanied by autonomic dysfunction, 1 case with blurred vision and neck resistance, and 1 case with tinnitus in both ears. There were no obvious abnormalities in blood routine, liver and kidney function, electrolytes, and coagulation function in 8 cases. The results of the lumbar puncture showed that the cerebrospinal fluid pressure was≤60 mmH 2O(1 mmH 2O=0.009 8 kPa) in 7 cases, and 2 cases were so low that they were undetectable. One patient had normal cerebrospinal fluid pressure (90 mmH 2O). The routine results of cerebrospinal fluid showed 4 cases of an increased number of red blood cells and 2 cases of leukocytosis. The biochemical results of cerebrospinal fluid in all 8 cases were normal. All 8 patients underwent non-contrast MRI scan of the head, and 6 cases found abnormalities, including 2 cases of subdural hematoma, 1 case of subarachnoid hemorrhage, 1 case of brain tissue sinking, and 3 cases of intracranial venous sinus dilation (including 1 case with subdural hematoma). All 8 patients underwent MRI enhancement scan of the head, and 5 patients showed diffuse dural enhancement. Three patients underwent digital subtraction angiography myelogram and computed tomography myelogram, and 2 cases found dural cerebrospinal fluid leakage. One patient underwent magnetic resonance water imaging and no cerebrospinal fluid leakage was found. Eight patients were followed up for 38.5 (10.3, 63.0) months, after conservative treatment, 6 cases of headache relief or disappearance, 1 case relapsed and was admitted 1 week after discharge, non-targeted epidural blood patching (EBP) did not relapse, 1 case underwent non-targeted EBP after conservative treatment failure, headache relief, recurrence after 2 months, thoracic spine 3-4 space targeted EBP, headache disappeared, did not recur. Conclusions:The present study indicate that SIH prevalence in young age is common, the main symptom is orthostatic headache, accommodated with multiple clinical symptoms with various imaging abnormalities. Most patients with SIH can be treated conservatively, if the effect is not good, non-targeted or targeted EBP is feasible.
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OBJECTIVE：To prov ide re ference for the development of biomedical industry in China. METHODS ：The policies and documents issued by 169 national high-tech industrial development zone （hereinafter reffered to as “National high-tech zone ”） official websites from Jan. 2010 to Dec. 2019 were collected to screen policies specifically for the biomedical industry and the development policy of biomedical industry mentioned in all industrial policies. Excel 2019 software was used to summarize and analyze policy information. Gensim package was used to preprocess the policy texts and construct LDA topic model to extract the potential semantic information from the policy texts. RESULTS ：A total of 518 policy texts were collected ，including 58 617 effective words ；high-frequency words included project ，talent，support，subsidy，innovation，etc.；8 themes were extracted ， ranked by theme intensity as technological innovation ，talent construction ，financing support ，project financial support ，tax incentives，resource guidance ，export trade ，and construction of small and medium-sized enterprises ，with the intensities of 0.299， 0.168，0.134，0.116，0.113，0.063，0.058 and 0.049，respectively. CONCLUSIONS ：The biomedical industry policy of the national high-tech zone is mainly based on technological innovation ，talent construction and financing support ，and lacks attention to the construction of small and medium-sized enterprises ，resource guidance ，and export trade. In the future ，the national high-tech zone ’s policy support and system construction for the biomedical industry should focus on improving policy incentives and balancing the proportion of policy applications in various fields ；encourage enterprises to expand overseas markets ，learn overseas advanced technologies ，and strengthen multilateral cooperation in scientific research and other fields ；support the corresponding policies to enhance exchanges and cooperation between enterprises ，give play to the leading role of leading enterprises and famous brand products ，and promote the development of small and medium-sized enterprises.
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OBJECTIVE：To provide refer ence for improving the innovation efficiency of Chinese pharmaceutical industry and promoting the high-quality development of the pharmaceutical industry. METHODS ：Using local economic development ，policy support，industrial foundation and innovation foundation as environmental variables ，three-stage data envelopment analysis （DEA） was used to explore the change regularity of innovation efficiency of the pharmaceutical industry by collecting related data such as input，output and invironment of 31 provinces（autonomous regions ，municipalities）in China during 2012-2016 and in 2018 from China Statistical Yearbook and China High-tech Industry Statistical Yearbook . RESULTS & CONCLUSIONS ：The innovation efficiency of the pharmaceutical industry in 18 provinces（autonomous regions ，municipalities）were overestimated ，and other 13 provinces（autonomous regions ，municipalities）was underestimated. The innovation efficiency of Fujian ，Heilongjiang，Jilin， Jiangxi，Yunnan，Liaoning and Chongqing before adjustment were overestimated 0-0.1，Shaanxi，Hainan，Gansu and Shanxi were overestimated 0.1-0.3，Inner Mongolia ，Guizhou，Guangxi，Xinjiang and Ningxia were overestimated 0.3-0.5；while the innovation efficiency of Anhui ，Hunan，Shanghai，Beijing，Hebei，Sichuan，Tianjin and Henan were underestimation 0.1-0.3，Hubei， Jiangsu，Zhejiang，Shandong and Guangdong had an underestimation of 0.3-0.5 before adjustment. Tibet ，Qinghai and Guangdong were greatly affected by environmental factors. The innovation efficiency in Tibet and Qinghai before adjustment were overestimated by 0.603 and 0.538 compared with after adjustment ，while Guangdong was underestimated by 0.470. The innovation efficiency value of the eastern and central regions of China before adjustment was underestimated ，while the northeastern and western regions were overestimated overall. B efore the adjustment，the order of innovation efficiency in descending order was the central ， western， eastern and northeastern liying@163.com regions，and after the adjustment ，it became the eastern ，central， northeastern and western regions. The innovation efficiency of Chinese pharmaceutical industry is greatly affected by the environment ，so all localities shou ld pay attention to the po licy support for the pharmaceutical industry and strengthen the policy guiding role for the pharmaceutical industry ；improve the industrial chain and supporting measures to create a good innovation environment ；promote the flow of innovation resources in different regions ，strengthen the cooperation and exchange among regions ，so as to improve the innovation efficiency of Chinese pharmaceutical industry and promote the high-quality development of the pharmaceutical industry.
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Since the outbreak of new coronavirus infection (COVID-19) in Wuhan, Hubei in December 2019, a total of 80 424 patients have been diagnosed until March 3, 2020, which has caused significant inpact in national health and economics. Module hospital played a vital role in effectively controlling the source of infection and cutting off the transmission channels.Compared with the CT room in a conventional hospital, the cabin CT is very different in terms of infection area settings, protective isolation measures and inspection procedures. This article covers CT room design, staffing responsibilities, division of infected areas, inspection procedures, protection and disinfection, and other aspects.
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OBJECTIVE： To provide reference for the coordinated development of the pharmaceutical manufacturing industry and regional economy in the central and western regions of China. METHODS： With reference to China High-tech Industry Statistical Yearbook in 2011-2017 and China Statistical Yearbook in 2011-2017， relevant data of 14 provinces （municipatities， automous regions） in the central and western regions during 2010-2016 were collected， and a comprehensive evaluation index system and coupling coordination model of pharmaceutical manufacturing industry and regional economy were constructed， and the coupling coordinated relationship between pharmaceutical manufacturing industry and regional economy in the central and western regions of China were analyzed. RESULTS & CONCLUSIONS： During 2010-2016， the comprehensive development level of the pharmaceutical manufacturing industry and the regional economy in the central and western was on the rise， but the growth rate was relatively slow； the provinces in the central region were better than the western provinces. There were obvious coupling characteristics between the pharmaceutical manufacturing system and the regional economic system， and the coupling coordination degree had an obvious upward trend in 2010-2016. Although there were fluctuations during the period， the fluctuation degree was small and the overall trend was rising. Among them， pharmaceutical manufacturing industry and regional economy of Shanxi， Guangxi， Yunnan and Xinjiang had the same degree of coupling and coordination， which showed that the coupling coordination degree of them were greatly affected by the development of pharmaceutical manufacturing industry； Inner Mongolia， Jiangxi， Henan， Hubei， Chongqing， Sichuan， Shaanxi and Gansu had same coupling coordination degree and fluctuation course of regional economic development， which showed that the coupling coordination degree of them was greatly influenced by the development of regional economy； Anhui and Hunan had same coupling coordination degree with the development of pharmaceutical manufacturing industry and regional economy. The development of their pharmaceutical manufacturing industry and regional economy were on the rise， which showed that they were both in the rising stage of development. The mutual promotion of pharmaceutical manufacturing industry and regional economy showed that their coupling coordination was also improving. It is suggested to speed up the adjustment of industrial structure， promote the industrial transfer； pay attention to talent education， improve the talent reserve mechanism； increase the investment in fixed assets， improve infrastructure construction in central and western regions； increase the per capita disposable income of residents， promote the development of regional econorny，so as to premote the coordinated development of pharmaceutical manufacturing industry and regional economy.
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Objective To evaluate the effect of morphine on the proliferation and migration of human hepatocellular carcinoma (HCC) cells in an in vitro experiment.Methods The experiment was performed in 2 parts.Experiment Ⅰ Human HCC cells were inoculated in 6-well plates at a density of 2×105 cells/well (2 ml/well) and divided into 6 groups (n=12 each) using a random number table:control group (C group) and 10,25,50,100 and 200 ng/ml morphine groups (M1-M5 groups).Morphine at the final concentration of 10,25,50,100 and 200 ng/ml was added in M1-M5 groups,respectively.The equal volume of phosphate buffer solution was added in group C.The cells were cultured or incubated for 48 h.The expression of μ1-opioid receptor (MOR1) mRNA was measured by real-time polymerase chain reaction.The expression of MOR1 was detected by Western blot in C and M4 groups.Experiment Ⅱ Human HCC cells were inoculated in 96-well plates (1×103 cells/well) or in Transwell chambers(200 μl) and divided into 2 groups (n=9 each) using a random number table:control group (C group) and morphine group (M group).Morphine was added at the final concentration of 100 ng/ml in group M,and the equal volume of phosphate buffer solution (final volume 100 μl/well) was added in group C.The cells were cultured or incubated for 7 days.The cell proliferation was detected by methyl thiazolyl tetrazolium assay at 1-7 days of incubation or culture.The cell migration was determined by Transwell chamber assay at 30 h of incubation or culture.Results Experiment Ⅰ Compared with group C,the expression of MOR1 mRNA was significantly up-regulated in M1-M5 groups,and the expression of MOR1 was significantly up-regulated in group M4 (P<0.01).Compared with group M4,the expression of MOR1 mRNA was significantly down-regulated in M1-M3 and M5 groups (P<0.01).Experiment Ⅱ Compared with group C,the cell proliferation was significantly enhanced on 4th-7th days of incubation,and the number of cells passing through Transwell chambers was increased in group M (P<0.05 or 0.01).The cell proliferation was gradually enhanced on 4th-7th days of incubation in group M (P<0.05).Conclusion Morphine can promote the proliferation and migration of human HCC cells,and the mechanism is related to up-regulation of MOR1 expression in an in vitro experiment.
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Objective To analyze the causes and treatment methods of early complications after central systemic-pulmonary shunt in complex cyanotic congenital heart diseases.Methods Two hundred and twelve cases of central systemic-pulmonary shunt in complex cyanotic congenital heart diseases were retro-spectively analyzed in order to explore the early postoperative complications and related treatment measures. Results There were 61 cases(28.77%)of the early postoperative complications,including severe low car-diac output syndrome in 27 cases,acute pulmonary edema in 14 cases,24 h shunt pipe blockage in 12 cases, and supraventricular tachycardia in 8 cases.All patients got followed up,average for(2.49 ±1.21 )years.Af-ter the systemic-to-pulmonary artery shunts,pulmonary vascular had significant growth,8 patients(3.77%) of them who pulmonary hypoplasia were promoted by transcatheter aortopulmonary collateral vessels.At the end of the follow-up,77 patients(36.32%)achieved the standard of radical surgery.Conclusion The factors affecting surgical survival rate include:enhancement of patients cardiac function and strictly handle operation indication before operation a clear operational view;rational surgical methods;treatment of complication with-out delay;strict,intensive care and synthesized treatment.
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Objective To study the antiproliferative effect of DX2, a piperazine derivate of β-elemene, on human hepatoma HepG2 cells. Methods Cell viability was measured by MTT method. Morphological changes were observed by phase contrast microscopy and acridine orange staining. Apoptotic cell ratio was measured by flow cytometric analysis. Protein level was detected by Western blot analysis. Results DX2 Induced apoptotic morphological changes in HepG2 cells and increased the ratio of apoptotic cells. Treatment of HepG2 cells with DX2 increased the Bax/Bcl-2 ratio, induced the activation of caspase-9 and caspase-3 and caused the degradation of ICAD which was the substrate of capase-3. Conclusion DX2 Induces HepG2 cell death via activation of intrinsic mitochondrial pathway.
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Objective To investigate the expressions of toll-like receptor 4 mRNA and nuclear factor-κB (TLR4-NF-κB) mRNA in lung tissue of rats with acute paraquat poisoning.Methods Thirty male SD rats were randomly divided into two groups,namely normal saline group (NS group,n =6) and the PQ groups (n =24).The rats of PQ group were administered with 20 mg/kg PQ by intraperitoneal injection to establish the models of PQ induced lung injury.The saline was administered once instead in normal saline group.The rats of PQ group were sacrificed separately at 6 h,12 h,24 h,48 h and 72 hours after modeling,while at 6 hours the rats of normal saline group was sacrificed.The expressions of TLR4 mRNA,NF-κB mRNA,and the levels of tumor necrosis factor-α and interleukin-6 in lung (serum) of rats were detected.Meanwhile,pathological changes of the lung tissue were examined under optical microscope.Results There were no histopathological changes such as alveolar edema,hemorrhage and inflammatory cell infiltration found in NS group other than in PQ group.At the 72 h,the expressions of TLR4 mRNA (9.61 ±0.21),NF-κB mRNA (5.62 ± 0.24),and the levels of TNF-α (153.08 ± 5.02) pg/ml,and interleukin-6 (230.08 ± 10.64) pg/mL in lung tissue of rats were significantly higher in PQ group than those in control group (P ＜ 0.01).Conclusions In rats after PQ poisoning,the expressions of TLR4 mRNA,NF-κB mRNA,and the levels of TNF-αand IL-6 were higher than those in normal rats,and the TLR4-NF-κB pathway could play an important role in lung injury of rats with PQ poisoning.
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BACKGROUND:The treatment of pulmonary hypertension secondary to congenital heart disease has been a hot topic in the clinical research on cardiac surgery. Although traditional drugs for reducing pulmonary hypertension have excelent effects, there are some defaults, such as difficult monitoring and rebounding phenomenon after drug withdrawal. The traditional heart dacron graft is prone to cause complications, such as deformation, thrombosis, embolism, hemolysis and infection. OBJECTIVE:To investigate the effect of glutaraldehyde-fixed bovine pericardium patch and aerosolized iloprost in patients with pulmonary hypertension secondary to congenital heart disease. METHODS:Ninety patients with pulmonary hypertension due to congenital heart disease underwent a surgery. Glutaraldehyde-treated bovine pericardium patch were used to repair cardiac septal defect, and then aerosolized iloprost was applied after operation, administered for 3 days according to 30 ng/min/kg, every 4 hours in the first 12 hours of a day, and every 6 hours in the resting 12 hours. Mean arterial pressure, mean pulmonary arterial pressure, systemic vascular resistance index, pulmonary vascular resistance index were recorded before inhalation, immediately after inhalation, and 30 minutes after inhalation. The pericardium-associated complications, and cardiac function were also observed at folow-ups. RESULTS AND CONCLUSION: The involved 90 cases were detected by echocardiography. The results showed that, al the flaps were closed, there was no shunting or echo discontinuation of atrial septum. The heart contraction function was normal. No pericardium-associated complications were found. There was no significant difference in the mean arterial pressure and systemic vascular resistance index in al patients at different time points. The mean pulmonary arterial pressure and pulmonary vascular resistance index immediately after inhalation were significantly lower than that before inhalation (P < 0.01). The decrease was also significant 30 minutes after inhalation (P < 0.05). The intervention of glutaraldehyde-fixed bovine pericardium patch and aerosolized iloprost is safe and effective to treat patients with pulmonary hypertension secondary to congenital heart disease.
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Clinical data and manifestations on muhi-slice spiral CT (MSCT) of 11 patients with disseminated peritoneal adenomucinosis (DPAM) were retrospectively reviewed.The CT manifestations were also compared with surgical and histopathological findings.MSCT findings showed a large amount of gel-like ascites in 9 cases and local cystic masses in 2 cases.Among 9 cases with a large amount ascites,abdominal multiple cystic masses were shown in 5 case,and infiltration of the greater omentum and mesentery in 5 cases.Hepatic scalloping was found in 6 cases ; parenchymal invasion of the liver or spleen were showed in 5 cases; calcification of the cystic masses in 5 cases.Ovary mueinous cystadenoma was presented in 3 female patients.Enlarged lymph nodes and omental cake were not found in all cases.The results indicate that the characteristic MSCT manifestations of DPAM include diffuse gel-like ascites,multiple cystic masses with or without calcification,hepatic scalloping and parenchyma invasion.
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The study examined the association between calcified liver metastases and the histopathology of the primary colorectal carcinoma in Chinese. The clinical, pathological and CT data were retrospectively analyzed in 210 patients (mean age: 54.2 years) with liver metastases from colorectal carcinoma. Plain CT scanning and contrast-enhanced scanning were performed in all the patients. For the contrast-enhanced examination, iohexol was injected by using a high pressure syringe at a flow rate of 2.5-3.0 mL/s. The arterial phase lasted approximately 25 s and the portal venous phase about 60 s. All patients had no history of chronic liver diseases and had never received interventional treatments. χ(2)-test was used to analyze the rate of calcification in the liver metastasis from colorectal cancer of different differentiation degrees. Among the 210 cases of liver metastases, 22 patients (10.5%) were found to have calcified liver metastases on CT scan. Two patients with calcified liver metastasis received lumpectomy and developed calcification in recurrent tumors. Another two patients had calcification in newly developed tumor masses. And the calcification in the newly developed masses was similar to that of their primary counterparts in terms of morphology and distribution. On the enhanced CT scan, the tumors exhibited no enhancement during hepatic arterial phase and showed slight rim enhancement during portal venous scan in the 22 cases. The calcification became obscure on contrast-enhanced scans. Histopathologically, the primary tumors were well-differentiated adenocarcinoma in 6 cases, moderately-differentiated adenocarcinoma in 10, poorly-differentiated adenocarcinoma in 4 and mucinous adenocarcinoma in 2 among the 22 cases. No statistical correlation was noted between the incidence of calcified liver metastasis and the pathological subtypes and differentiation degrees of the primary colorectal carcinoma. It was concluded that calcified liver metastases may result from colorectal adenocarcinomata of different differentiation degrees or mucinous adenocarcinomata in Chinese population. There is no correlation between calcification of liver metastases and the pathological subtype of the primary colorectal carcinoma in Chinese, which is different from the findings that calcified metastases were associated with colorectal mucinous adenocarcinoma in other ethnic groups.
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Adult , Aged , Female , Humans , Male , Middle Aged , Adenocarcinoma , Pathology , Adenocarcinoma, Mucinous , Pathology , Calcinosis , Pathology , Colorectal Neoplasms , Pathology , Liver , Pathology , Liver NeoplasmsABSTRACT
The study examined the association between calcified liver metastases and the histopathology of the primary colorectal carcinoma in Chinese. The clinical, pathological and CT data were retrospectively analyzed in 210 patients (mean age: 54.2 years) with liver metastases from colorectal carcinoma. Plain CT scanning and contrast-enhanced scanning were performed in all the patients. For the contrast-enhanced examination, iohexol was injected by using a high pressure syringe at a flow rate of 2.5-3.0 mL/s. The arterial phase lasted approximately 25 s and the portal venous phase about 60 s. All patients had no history of chronic liver diseases and had never received interventional treatments. χ(2)-test was used to analyze the rate of calcification in the liver metastasis from colorectal cancer of different differentiation degrees. Among the 210 cases of liver metastases, 22 patients (10.5%) were found to have calcified liver metastases on CT scan. Two patients with calcified liver metastasis received lumpectomy and developed calcification in recurrent tumors. Another two patients had calcification in newly developed tumor masses. And the calcification in the newly developed masses was similar to that of their primary counterparts in terms of morphology and distribution. On the enhanced CT scan, the tumors exhibited no enhancement during hepatic arterial phase and showed slight rim enhancement during portal venous scan in the 22 cases. The calcification became obscure on contrast-enhanced scans. Histopathologically, the primary tumors were well-differentiated adenocarcinoma in 6 cases, moderately-differentiated adenocarcinoma in 10, poorly-differentiated adenocarcinoma in 4 and mucinous adenocarcinoma in 2 among the 22 cases. No statistical correlation was noted between the incidence of calcified liver metastasis and the pathological subtypes and differentiation degrees of the primary colorectal carcinoma. It was concluded that calcified liver metastases may result from colorectal adenocarcinomata of different differentiation degrees or mucinous adenocarcinomata in Chinese population. There is no correlation between calcification of liver metastases and the pathological subtype of the primary colorectal carcinoma in Chinese, which is different from the findings that calcified metastases were associated with colorectal mucinous adenocarcinoma in other ethnic groups.
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Objective To evaluate the dose reduction technology using in CT-guided percutaneous lung biopsy of pulmonary lesions using automated core needle biopsies (ACNB).Methods 412 ACNB cases included 146 consecutive conventional patients (group A,120 kV/100 mA) and 266 consecutive patients (group B,120 kV/20 mA,low-dose scanning,reduce scanning width and scanning frequency).The quality of images was compared by grain homogeneity,fine structure,clearness of tissue interface and artifacts.The total diagnostic accuracy rate,the examination time and radiation dose between group A and group B were compared.Results The fine structure of group B was significantly lower (X~2 ＝7.0508,P ＜ 0.05).The total diagnostic accuracy rate was 95.9% vs 95.1% (X~2 ＝0.1296,P ＜ 0.05).The examination time for biopsy procedure was (16 ±2.2)min vs (15.9 ±2.0)min (t ＝ 1.3579,P ＜ 0.05) ,and the mean effective dose (E) was (1.74 ± 0.7) mSv vs (0.59 ± 0.14) mSv (t ＝ 19.3415 ,P ＜ 0.05) .The E of group B decreased by 66%.Conclusions ACNB is a feasible and accurate method for diagnosing pulmonary lesions,and the E can significantly reduce the dose received in low-dose scanning.
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Objective:To evaluate radiography,CT,MRI,and DSA in the diagnosis of chondrosarcomas in pelvis.Methods:A retrospective review was conducted of 14 radiographs,14 CT scans,9 MR images and 6 DSA obtained in 14 patients with histologically proved chondrosarcoma.Results:The sites of tumor occurrence were ilium(4 cases),sacrum(3 cases),both ilium and sacrum(6 cases),and ischium(1 case).Mean tumor size at diagnosis was 9.3 cm(range,3～16cm).Of the 14 cases,allmanifested osteolytic lesions associated with cortical destruction on radiography,CT scans and MR images.Intraosseous calcification suggestive of a cartilage tumor was present in 9 cases on radiographs and 14 cases on CT scans.An associated soft-tissue mass was identified in 11 cases on radiographs,14 cases on CT scans and 9 cases on MR images.Ten of 14 CT scans and 8 of 9 MR images were obtained after intravenous administration of contrast material.The tumors demonstrated heterogeneous enhancement on CT scans and MR images.Six cases of DSA showed abundant blood supply and above 2 feeding arteries.The surgery was done 2～3 days after embolism by spongia gelatinosa.Conclusions:Destruction of bone,soft-tissue mass and cartilage calcification are the characteristic imaging features of the chondrosarcoma.Each imaging modality has advantages and disadvantages.CT and MR images can reflect the pathology of the pelvic chondrosarcoma.Correct diagnosis before operation is useful to the surgeons.
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The MRI appearances of 7 adult patients with pathologically proven intracranial primitive neuroectodermal tumors (PNET) were retrospectively analyzed. The MRI features were compared with findings in pathology and surgery. In this group, the tumor masses were most commonly found in the semisphere of cerebrum and in the vermis of cerebellum. They were relatively large and 4 were in lobulated shape. All of them had well-defined margins. MR images showed the tumors to be mildly or obviously hypointense on T1-weighted images and hyperintense on T2-weighted images. Most masses had heterogeneous appearances with some cystic and necrotic areas. Intratumoral haemorrhage and focal calcification were occasionally seen. Mostly, there was no or only mild surrounding edema. Marked inhomogeneous contrast enhancement on MRI was seen in 6 cases except one. Two patients with multiple intracranial metastases were revealed on MR images. In this series, there was good correlation between MRI features and findings in pathology and surgery. These results showed that certain MRI features might suggest the diagnosis of intracranial PNET in adults. MRI is an effective technique to detect these tumors and is helpful to treatment planning and follow-up.
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Adult , Female , Humans , Male , Brain Neoplasms , Diagnosis , Pathology , Magnetic Resonance Imaging , Neuroectodermal Tumors, Primitive , Diagnosis , Pathology , Retrospective StudiesABSTRACT
The MRI appearances of 7 adult patients with pathologically proven intracranial primitive neuroectodermal tumors (PNET) were retrospectively analyzed. The MRI features were compared with findings in pathology and surgery. In this group, the tumor masses were most commonly found in the semisphere of cerebrum and in the vermis of cerebellum. They were relatively large and 4 were in lobulated shape. All of them had well-defined margins. MR images showed the tumors to be mildly or obviously hypointense on T1-weighted images and hyperintense on T2-weighted images. Most masses had heterogeneous appearances with some cystic and necrotic areas. Intratumoral haemorrhage and focal calcification were occasionally seen. Mostly, there was no or only mild surrounding edema. Marked inhomogeneous contrast enhancement on MRI was seen in 6 cases except one. Two patients with multiple intracranial metastases were revealed on MR images. In this series, there was good correlation between MRI features and findings in pathology and surgery. These results showed that certain MRI features might suggest the diagnosis of intracranial PNET in adults. MRI is an effective technique to detect these tumors and is helpful to treatment planning and follow-up.